Léa Domenach began directing at an early age, directing her first short film while studying film at Columbia University.

In 2021, she created and wrote the series "Jeune & Golri", broadcast on OCS. The same year, she co-wrote "Les Murs Blancs" with her brother Hugo.

Two years later, Léa Domenach wrote and directed her first feature film, "Bernadette", about the former First Lady and wife of Jacques Chirac. Part satire, part offbeat biopic, this comedy enabled  her to direct Catherine Deneuve in the lead role. For the 2024 César ceremony, "Bernadette" is eligible for the César for the Best First Feature Film.